Abstract: Statistical dates show that the failure rate and defect rate of 220 kV GIS are obviously higher when arranged outdoor than indoor, while the occupied area and civil engineering investment of indoor layout increase significantly. The research of compact indoor layout scheme in this paper is based on the investigation results of five 220 kV GIS domestic mainstream manufacturers. Research results including:optimization of 220 kV GIS room width to 11 meters, recommend using double or glyph overhead line when the field width is limited, recommend cancelling independent architecture of outlet and inlet line and decorating the outlet line equipment on the roof when the field length is limited, etc. The above research results can be applied to solve the reserve site tension situation of the 220 kV GIS indoor layout, and further reduce the cost of civil engineering while improving the economic benefit of whole life cycle.