Abstract: The advantages and disadvantages of different ground treatment schemes of power plant engineering in karst region have been invesigated in this paper. Based on the foundation treatment process of a domestic gas turbine power plant, this paper compared the two soil-treatment methods from three aspects, such as the ease of construction, economy and treatment effects, and summarized the merits and demerits of the two methods. The comparison results show that only depending on the geological characteristics and specific structure features and security levels, using two kinds of ground treatment schemes in combination, we can achieve a balance between safety and economy, and achieve the best effect of the foundation treatment.