Abstract: Introduction Aimming to satisfy the state's "ultra-clean" emission requirements for the emission of flue gas pollutants from thermal power plants. Method With the research on the technology of dust removal and desulphurization in a thermal power plant in Guangdong, an integration ultra-clean technology of high-efficiency desulphurization and ultra-clean dust elimination has been put forward and applied successfully. Based on the conventional scheme on dust removal and desulphurization, the integration of high-efficiency desulphurization and ultra-clean dust elimination technology was researched and optimized, and the equipment of MGGH and electrostatic dust and mist eliminator was added. The dust and sulfur dioxide was removaled synergistically, and the temperature of flue gas outlet of the chimney was improved, and the concentration of liquid drop and dust was reduced. Result The results shows that the concentration of dust and sulfur dioxide is only 2.2 mg/Nm³和16.7 mg/Nm³.It means satisfy and is better than the requirement of "ultra-clean",and the gypsum rain is eliminated. Conclusion With this technology, it is possible to satisfy the "ultra-clean" emission requirements without WESP, and it is a guidance for the newly-build and reformed project.