Introduction  The development of information technology leads the development trend of the new era. Information technology promotes the progress of nuclear power generation technology to intelligentization and even smartization, while also ensuring the safe development of nuclear power generation.

  Method  The positioning association of information, nuclear power generation, and the intelligentization of nuclear power generation was provided. The application of information technology in future nuclear power generation was studied. The development trend of advanced nuclear power generation was analyzed.

  Result  The future nuclear power generation should first be information-based nuclear power generation, followed by intelligent nuclear power generation, and then possibly smart nuclear power generation. The characteristics of 5G low delay can make the nuclear power generation system more accurate, and the nuclear system can be accurately adjusted to operate faster and respond in time. Cloud computing can also find problems in nuclear power generation's complex mass of data. Big data can analyze the root causes of problems in a timely manner. Quantum technology can enhance the core fuel function. Artificial intelligence machine data capture and neural networks learn to process and apply information more precisely.

  Conclusion  Informationization is also a new quality productivity revolution, and information technology promotes the progress of nuclear power generation technology to intelligent development. The intelligence of nuclear power generation is the future trend of advanced nuclear power generation development. The upgrading of information technology is the leading driver of nuclear power generation. Ensuring nuclear power generation safety requires the assistance of information. Network information technology is the central link to build a comprehensive nuclear and solar energy system.