Abstract: turbo generator is the heart of the power plant, and is a precision instrument for high speed operation. In order to ensure the normal operation of the turbo generator, as the foundation of its supporting structure, the design requirement (especially settlement control) is very high. The settlement calculation method provided by the foundation design specification is applicable to the independent foundation, and the calculation result is a settlement of a point, which is not suitable for the turbine generator foundation. There are three parts in this paper. First, through appropriate assumption, the settlement calculation method based on the independent foundation is extended to other arbitrary foundation forms. Second, based on the actual engineering practice example, the design method based on the above assumptions is shown; third, the author tries to simplify the design process, and to establish a more general standard for the eccentric design of dynamic machine and other building and structure, which is sensitive to uneven settlement.