Introduction  With the promotion of comprehensive utilization of natural gas and the encouragement of clean energy power generation， the construction of large combined-cycle power plant is one of the important forms to achieve this goal.

  Method  In this paper， through case study， comparative analysis and summary， the main power house arrangement design of the large single-shaft combined-cycle power plant was studied.

  Result  The paper states the main power house design principle of the large single-shaft combined-cycle power plant， puts forward two arrangement schemes that of the combined power house and the independent power house， and summarizes the technical characteristics and economic efficiency of the two arrangement schemes.

  Conclusion  The combined power house arrangement scheme and the independent power house arrangement scheme are both mature， reliable and each has its own characteristics. Because of the advantages of saving land， saving investment and beautiful appearance， the combined power house arrangement is worth to be adopted and popularized. And also it provides reference for the main power house layout design of the large combined-cycle power plants in the future.